The relationship between vascular endothelial growth factor-A serum level and the severity of diabetic peripheral neuropathy

Abstract Background and aims Diabetic peripheral neuropathy (DPN) is a common microvascular complication in type 2 diabetes mellitus (T2DM). The nerve fibers injury caused by the interaction between metabolic vascular factors. Vascular endothelial growth factor (VEGF) an essential for cells. We aimed to investigate relation VEGF-A serum level degree of DPN. Results This cross-sectional study was conducted on 81 patients with T2DM. Based combined clinical electrophysiological assessment, 67 (82.7%) were diagnosed which 32 (39.5%) had subclinical neuropathy, whereas 35 (43.2%) confirmed cases Patients DPN longer duration DM higher values glycosylated hemoglobin (HbA1c). Although mean diabetic without than that DPN, this difference did not reach statistical significance ( P = 0.07). However, significantly compared < 0.001). Conclusion found be finding studied sample T2DM patients. Longer poor glycemic control may risk factors development severe Low levels lead more